Brief medical knowledge of Parkinsonism and Parkinson's disease

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The triad hypokinesia, tremor and rigidity, producing a typical Syndrome was described by Sir Parkinson in 1819. Parkinsonism is caused by disorders of the basal ganglia. Cosy and direct connections between neurons in the substantia nigra in the midbrain and corpus stratum to and fro exist. These are called the nigrostriatal and striatonigral roads.

In the nigrostriatal pathway dopamine (striatopetal) acts as a neurotransmitter, while underway (striatofugal) striatonigral acetylcholine is the neurotransmitter. The normal functioning of the basal ganglia system depends on the action balanced between striatopetal and striatofugal systems. The result of an imbalance between these systems as a result of the depletion of dopamine in the presence of normal acetylecholine smounts parkinsonism. Akinesia and stiffness probably the result of the decreased dopamine. Hyperactivity of the acetylcholine system produces features such as excessive sweating, tremor, Seborrhea, orthostatic hypotension. You know now that other neurotransmitters such as enkephalins and gamma aminobutyric acid also have a role in the normal operation of the system of basal ganglia. It is likely that with the accumulation of new evidence, the concept of basal ganglia disease need to modify. More coherent pathological finding is loss of pigment in the substantia nigra and cellular. The disease is not uncommon, the majority of cases are over the age of 40. Both sexes are equally affected. Startup is insidious for a period of two to three years for the condition may become only clinically evident in his appearance, at the latest.

Clinical classification
Parkinsonism syndrome can occur several disorders that affect the basal ganglia.
1. Main Parkinsonism (Parkinson's disease): in this condition, there is no primary degeneration of neurons in the substantia nigra.
2 Secondary Parkinsonism:
(a) drug induced-butyrophenones, phenothiazines, reserpine.
(b) Postencephalitic-Parkinsonism observed to develop after several years in subjects which have suffered from encephalitis lethargica. Other types of encephalitis can also lead to parkinsonism. Addition of the basal ganglia, other parts of the nervous system can also be affected.
3. Tertiary Parkinsonism: among them include disorders such as Wilson's disease, Huntington's disease, poisoning by carbon monoxide, manganese, etc.

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Essential information on anti drugs of ischemic heart disease

Anti-ischemic drug Trimetazidine retains the metabolism of cells that have been exposed to the ischemia and hypoxia energy. Angina patients treated with this drug shown increases coronary flow reserve.

Doctors prescribe Trimetazidine for the treatment of angina pectoris. This metabolic drug anti-ischemic or anti-anginal helps improve the utilization of glucose myocardial by inhibition of metabolism of fatty acids.

Mechanism of action:

Mentioned by name brand, MR Vastarel Trimetazidine is available in Tablet 35 mg dose form. Metabolism of cells are exposed to the ischemia and hypoxia energy may be retained with the help of this drug that prevents that the reduction in intracellular adenosine triphosphate levels. The present drug ensures the flow of sodium potassium enhanced transmembranous and proper functioning of ionic pumps as well as maintaining cellular homeostasis. Also, is known to inhibit oxidation of fatty acids in the blood vessels.

Important information

Trimetazidine is taken with a full stomach. Not recommended for use by pregnant women, lactating women, or people with hypersensitivity. Adverse reactions to this drug include vomiting, nausea, and gastrointestinal disorders. In some countries, Trimetazidine is marketed as a treatment for tinnitus and dizziness. This is due to the fact that you have a high profile safety and tolerability, with no known drug interactions.

Other therapeutic benefits

Trimetazidine is also known for its cardioprotective effects as confirmed in human isquemia-reperfusion. The drug works in patients who undergo bypass with the arrest of cardioplegica and percutaneous coronary revascularization surgery. Studies showed that a (MR) form of the modified version of this medication when taken twice a day, is bioequivalent to the previous formulation taken three times daily.

Meanwhile, controlled studies in patients with angina showed Trimetazidine increases coronary flow reserve and thus control quick sudden changes in blood pressure, significantly decreasing the frequency of angina attacks leader in the use of nitrate reduction.

For diabetic patients with coronary artery disease, Trimetazidine helps improve left ventricular function. Trimetazidine has demonstrated efficacy in the treatment of patients with heart failure. It is recommended to consult your doctor before taking this medicine.