Scientists have identified chemicals - the new principle of antibiotic action. Research reported in "natural chemical biology" is supposed to serve as a basis for the creation of following generation drugs which is to combat highly current drug-resistant bacteria.
In the past 40 years, in spite of extensive development in medicine, industry were discovered only two new groups of chemical compounds that are able to suppress the development of single-celled organisms or because of his death. In this case, pathogens, due to the extensive use of existing antibiotics, begin to develop resistance to drugs, and increasingly more complicated work of phyisicians.
Eric Brown and his colleagues at McMaster University in Canada using a new approach to find chemical compounds that can destroy micro-organisms. This approach is based on genetic methods. Thanks to the developed techniques, researchers could try in antibacterial activity of certain compounds really fast and also to identify the mechanism of their effects on microbes. Of a result, scientists have found a chemical compound, called MAC13243. It is able to inhibit microbial activity previously in an unknown way. The fact is that all existing antibiotics or inhibit the synthesis of bacterial membrane, or working DNA Microorganisms inhibit key bacterial protein synthesis. In contrast to existing antibiotics, MAC13243 protein inhibits the work of LolA, which is located on the surface of the membrane cell micro-organisms and provides a link for many important biologically active substances.
"We find out what is shortly before by another aspect of the researchers of the physiology of bacteria can actually be used to create new types of antibiotics." "Gave us the opportunity to make a new perspective on the problem of drug development,"-says Brown.
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