Showing posts with label medical. Show all posts
Showing posts with label medical. Show all posts

Friday, December 10, 2010

Brief medical knowledge of Parkinsonism and Parkinson's disease

I am Dr. Funom Theophilus Makama (while still a student). I am a candidate for Cardio-thoracic surgeon and also I love to write. I write articles (especially...)


The triad hypokinesia, tremor and rigidity, producing a typical Syndrome was described by Sir Parkinson in 1819. Parkinsonism is caused by disorders of the basal ganglia. Cosy and direct connections between neurons in the substantia nigra in the midbrain and corpus stratum to and fro exist. These are called the nigrostriatal and striatonigral roads.


In the nigrostriatal pathway dopamine (striatopetal) acts as a neurotransmitter, while underway (striatofugal) striatonigral acetylcholine is the neurotransmitter. The normal functioning of the basal ganglia system depends on the action balanced between striatopetal and striatofugal systems. The result of an imbalance between these systems as a result of the depletion of dopamine in the presence of normal acetylecholine smounts parkinsonism. Akinesia and stiffness probably the result of the decreased dopamine. Hyperactivity of the acetylcholine system produces features such as excessive sweating, tremor, Seborrhea, orthostatic hypotension. You know now that other neurotransmitters such as enkephalins and gamma aminobutyric acid also have a role in the normal operation of the system of basal ganglia. It is likely that with the accumulation of new evidence, the concept of basal ganglia disease need to modify. More coherent pathological finding is loss of pigment in the substantia nigra and cellular. The disease is not uncommon, the majority of cases are over the age of 40. Both sexes are equally affected. Startup is insidious for a period of two to three years for the condition may become only clinically evident in his appearance, at the latest.


Clinical classification
Parkinsonism syndrome can occur several disorders that affect the basal ganglia.
1. Main Parkinsonism (Parkinson's disease): in this condition, there is no primary degeneration of neurons in the substantia nigra.
2 Secondary Parkinsonism:
(a) drug induced-butyrophenones, phenothiazines, reserpine.
(b) Postencephalitic-Parkinsonism observed to develop after several years in subjects which have suffered from encephalitis lethargica. Other types of encephalitis can also lead to parkinsonism. Addition of the basal ganglia, other parts of the nervous system can also be affected.
3. Tertiary Parkinsonism: among them include disorders such as Wilson's disease, Huntington's disease, poisoning by carbon monoxide, manganese, etc.


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Saturday, December 4, 2010

Nuclear medical imaging presents a new era of personalized medicine

Advances in nuclear medicine imaging are revolutionizing the practice of medicine. Provides information for specific patient that allows custom treatments adapted to the specific attributes of a disease and the patient's individual needs. Despite the fact that all persons are genetically similar, differences minutes in individual DNA that make a difference in how individuals respond to treatments. Therefore, a drug can work for one person and be ineffective or even harmful to another that affect how the drug is absorbed and used by the body. Personalized medicine recognizes that these differences in individuals play a role in health and treatment of disease.

Nuclear medical imaging provides information at molecular to show how specifically targeted tissue are functioning. Important psychologist gives information using the radiotracer and camera gamma external non-invasive that they would only be available from surgery or may not be available in all. Molecular image allows for detection of illness, often before they occur the symptoms or before other diagnostic tests can detect them. This allows early treatment and more favourable results.

With the increase of the specificity of nuclear medicine images, provided data will provide better care to the patient and reduce costs. You will allow the detection of patients at risk along with therapies individualized conducted early in the course of the disease for a better result. Will also allow for the monitoring of treatments in time real to determine how well are working and indicate the necessary changes.

Molecular Imaging is introducing a new era of personalized medicine that identifies the unique profile of each individual for the prevention or detection and treatment of disease. With better diagnosis and previous intervention together with the information added for better medicines and improved therapy options, improved results at a lower cost.

Thursday, December 2, 2010

Medical application of marijuana, the State of Arizona

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In the month of November, the State of Arizona passed Proposition 203, which would exempt certain people from controlled substances laws in the State of Arizona (and, due to an amnesty, also exempt them from the federal laws regarding the subject).? However, it will still take some time before medical marijuana is implemented as policy in Arizona.

The Arizona Department of Health Services has released a proposed timeline for the drafting of the rules surrounding the implementation of Proposition 203. So far, these are the important time periods that should be paid close attention to:

December 17, 2010: The first draft of the medical marijuana rules should be released and made available for comment on this date.

January 7, 2011: This will be the deadline for public comment on the first draft of rules mentioned above.

January 31, 2011: The second draft of the rules will be released on this date. Once again, it will be available for informal comment as in the draft referred to above.

February 21 to March 18, 2011: More formal public hearings will be held about the proposed rules at this time, after which the final rules will be submitted to the Secretary of State and made public on the Office of Administrative Rules website.

April 2011: The medical marijuana rules will go into effect and be published in the Arizona Administrative Register.

It is important that at all times throughout the consultation process, interested parties submit briefs and/or make oral presentations when permitted. Groups with interests contrary to those of medical marijuana advocates may also be making presentations, and may convince the State to unnecessarily restrict the substance or those who may qualify to access it if there is no voice to advocate in favor of patients' rights.

Some key points about Proposition 203's effects

-Physicians may prescribe medical marijuana for their patients under certain conditions. "Physician" is not defined in a way limited to normal medical doctors. Osteopaths licensed under Title 32, Chapter 17; naturopaths licensed under Title 32, Chapter 14; and homeopaths licensed under Title 32, Chapter 29 may all be eligible to recommend marijuana for their patients.

-In order to be prescribed medical marijuana, a person must be a "qualifying patient." A qualifying patient is defined as someone who has been diagnosed by a "physician" (as defined above) as having a "debilitating medical condition."

-Debilitating medical conditions include:
? Cancer, glaucoma, HIV positive status, AIDS, hepatitis C, amyotrophic lateral sclerosis, Crohn's disease, or agitation of Alzheimer's disease oo the treatment of these conditions.
? A chronic or debilitating disease or medical condition or its treatment that produces one or more of the following: Cachexia or wasting syndrome; severe and chronic pain; severe nausea; seizures, including those characteristic of epilepsy; or severe and persistent muscle spasms, including those characteristic of multiple sclerosis.
? Any other medical condition or its treatment added by the Department of Health Services pursuant to Section 36-2801.01.

This last qualifying condition is underlined because it is vitally important during the rulemaking process. Although Proposition 203 allows for the public to petition the Department of Health Services to exercise its discretion to add conditions under this section, bureaucracy is notoriously difficult to get to change any law. The initial discretionary rules for additional treatments could be exercised during the public consultations that occur between December and March, though this is not certain.

It is therefore important that, in the event that the addition of medical conditions is considered during the consultations, any stakeholder who wishes for medical condition not listed in the first two bulleted items above to lobby during the public consultation periods for the Department to add the additional medical condition to the list of debilitating medical conditions. In order to increase the prestige of any presentations made to justify adding medical conditions under Section 36-2801.01, it would probably be helpful to solicit the testimony of sympathetic Arizona-licensed medical doctors who can testify on paper and at the public hearings about why the proposed condition should be added. Documents showing that other jurisdictions, both in the United States and elsewhere, currently use marijuana as a treatment for the proposed condition would be helpful, as would medical journals on the subject.

It should be remembered that despite his cheery YouTube videos about the medical marijuana rule drafting process, Director of Health Services Will Humble wrote a submission in opposition to the passing of Proposition 203. He did so on the grounds that the FDA does not test the drug, and even though the federal government's anti-marijuana policy is well-known ?it should not be relied on as an authority for unbiased medical marijuana research. There is no reason to believe that Director Humble will be any less inclined to obstruct the use of medical marijuana during the rulemaking stage, and all proponents of medical marijuana should be sure to make their voices heard at the consultations to prevent the obstruction of the intent of Proposition 203.

Extent of Rulemaking during Consultations

There are other provisions in Proposition 203 which will be discussed during the initial rulemaking process, and they will probably be the main focus of the consultations. The consultations will create rules:
? Governing the manner in which the Department of Health Services will accept the petitions from the public previously mentioned, regarding the addition of medical conditions to the list of the already enshrined debilitating medical conditions.
? Establishing the form and content of registration and renewal applications submitted under the medical marijuana law.
? Governing the manner in which the Department will consider applications for and renewals of medical marijuana ID cards.
? Governing the various aspects around the newly legalized nonprofit medical marijuana dispensaries, including recordkeeping, security, oversight, and other requirements.
? Establishing the fees for patient applications and medical marijuana dispensary applications.

The most crucial part of the consultation period will be regarding the rules governing the establishment and oversight of medical marijuana dispensaries. If interest groups lobby the Department to make the recordkeeping, security, oversight, and other requirements around dispensaries too restrictive, it will have the effect of reducing the availability of medical marijuana to patients and driving up the price of medical marijuana due to the lack of supply. It could simply become too costly to comply with all of the regulations.

During this stage, it is important that stakeholders-particularly medical marijuana dispensaries from out-of-state, and perhaps pharmacists with a bit of economic knowledge-submit briefs explaining why certain proposed rules may have a negative effect on the patients this Proposition is supposed to help. The proposed rules have not come out yet, but when they do, they should be closely scrutinized for the possible negative impact that unnecessarily tough security and recordkeeping on nonprofit dispensaries might have on patients.
The other major factor in the rulemaking will have to do with the fees. The Department will be setting fees for medical marijuana dispensaries during the consultation period. Proposition 203 provides that the fees may not exceed $5,000 per initial application, and $1,000 per renewal. However, with some lobbying during the public consultation, it is possible that the actual fees will be much less since these are simply the maximum that the Department may charge.

Discrimination against Medical Marijuana Users

Under Proposition 203, discrimination against medical marijuana users will be prohibited in certain circumstances. ? Based on our analysis, a person may not:
? As a school or landlord, refuse to enroll someone or otherwise penalize them solely for their status as a medical marijuana cardholder, unless not doing so would result in the loss of a monetary or licensing related benefit under federal law or regulations.
? As an employer, discriminate against hiring someone, or terminate them or impose any conditions on them because they are a medical marijuana cardholder, unless not doing so would result in the loss of a monetary or licensing related benefit under federal law or regulations. Employers may still terminate employees if the employee is in possession of or impaired by marijuana on the premises of the place of employment or during the hours of employment.
? As a medical care provider, discriminate against a cardholder, including in matters of organ transplants. Medical marijuana must be treated as any other medication prescribed by a physician.
? Be prevented, as a cardholder, from having visitation custody or visitation or parenting time with a minor, unless the cardholder's behavior "creates an unreasonable danger to the safety of the minor as established by clear and convincing evidence."
Although there are certain prohibitions on discrimination, there are also provisions which permit discrimination against medical marijuana cardholders:
? Government medical assistance programs and private health insurers are not required to reimburse a person for their medical marijuana use.
? Nobody who possesses property, including business owners, is required to allow medical marijuana on their premises (this seemingly includes landlords who, although they cannot refuse tenants based on their being a cardholder, are permitted to prevent cardholders from bringing marijuana onto the landlord's property).
? Employers are not required to allow cardholders to be under the influence of or ingest marijuana while working, though the presence of marijuana in the body which is not of a sufficient concentration to cause impairment does not establish being under the influence of it.

Rules Related to the Establishment of Dispensaries

Although the final rules around security, recordkeeping, and other requirements for medical marijuana dispensaries will not be established until April 2011, there are certain requirements which are enshrined in Proposition 203 itself and can be known ahead of the time that the final rules come out. These minimal requirements may not be as restrictive as the final requirements which are published in April 2011.

? Medical marijuana dispensaries must be nonprofit. They must have bylaws which preserve their nonprofit nature, though they need not be considered tax-exempt by the IRS, nor must they be incorporated.
? The operating documents of the dispensaries must include provisions for the oversight of the dispensary and for accurate recordkeeping.
? The dispensary must have a single secure entrance and must implement appropriate security measures to deter and prevent the theft of marijuana and unauthorized access to areas containing marijuana.
? A dispensary must not acquire, possess, cultivate, manufacture, deliver, transfer, transport, supply, or dispense marijuana for any purpose other than providing it directly to a cardholder or to a registered caregiver for the cardholder.
? All cultivation of marijuana must take place only at a locked, enclosed facility at a physical address provided to the Department of Health Services during the application process, and accessible only by dispensary agents registered with the Department.
? A dispensary can acquire marijuana from a patient of their caregiver, but only if the patient or caregiver receives no compensation for it.
? No consumption of marijuana is permitted on the property of the dispensary.
? A dispensary is subject to reasonable inspection by the Department of Health Services. The Department must first give reasonable notice of the inspection to the dispensary.

Comparison to California's Medical Marijuana Law

The Arizona law is by no means the same as the law in California. There are certainly some differences between the two, though in some respects they are comparable. This is a comparative analysis of the two laws.

Similarities:
?
Both laws, as a practical matter, allow for broad discretion on the part of a physician to prescribe marijuana to patients who suffer from pain. In the Arizona law, "severe and chronic pain" is the legislated standard. In the California law, any "chronic or persistent medical symptom" that substantially limits the life of the patient to conduct one or more major life activities as defined by the Americans with Disabilities Act of 1990, or that if not alleviated, will cause serious harm to the patient's physical or mental safety, qualifies.
? Both laws have a number of illnesses which are automatically considered qualifying illnesses for the prescription of medical marijuana. These include, but are not limited to, AIDS, cachexia, cancer, glaucoma, persistent muscle spasms, seizures, and severe nausea.
? Both laws require the use of an identification card by those who have been prescribed medical marijuana, after the cardholders have gone through an initial application process in which the use of the drug has been recommended by a physician.
? Both states do not factor in the unusable portion of the marijuana plant in determining the maximum weight of marijuana that is permissible for possession by a cardholder.

Differences:
?
Though the rules have not been finalized, the Arizona law appears as though it will be regulated on the state level and therefore uniform across Arizona. The California law, however, is regulated significantly on the municipal level, and therefore the rules around dispensaries can vary greatly from one municipality to the next.
? The Arizona law provides a broader spectrum of people who are considered a "physician" for the purpose of prescribing medical marijuana. In California, only medical doctors and osteopaths are considered to be physicians. In Arizona, in addition to medical doctors and osteopaths, naturopaths and homeopaths will also be permitted to prescribe medical marijuana.
? In California, patients or their caregivers may grow marijuana plants in lieu of using a medical marijuana dispensary. In Arizona, patients may only grow marijuana or designate someone else to do so in lieu of visiting a dispensary on the condition that there is no dispensary operating within 25 miles of the patient's home.
? The maximum possession limit for marijuana in California is eight ounces per patient, whereas the limit is only 2.5 ounces per patient in Arizona.

-----This is not meant to be legal advice and is provided purely as an analysis of the current legislation. ?You should consult with an attorney to discuss these matters. ?We are available for consultations for this matter by appointment only and via prepayment of the consultation fee.

Wednesday, December 1, 2010

The importance of medical and pharmaceutical Research

There are many questions and controversial issues surrounding the health, and that is very important to the medical and pharmaceutical research for you. Not only will help you make informed decisions, even can save your life.

Many people suffer from a disease just sit and wait to your doctor to give them information. The problem is that this is simply not already.There are too many disorders, symptoms, treatments and procedures for doctors to follow all ellos.Esto can be a scary thought, but is the truth.

The best thing you can do is to start doing some medical and pharmaceutical research relating to disease or symptoms that you have.

What doctors Don't Know Will Hurt You?

Unfortunately is becoming increasingly clear that doctors are not as well informed as we would like fueran.Tenga note that this is not always to blame suya.Hay thousand things have to track each day and longer than not superhuman doctors things slide through cracks.

Also, many doctors do not really get the information you should companies assumes should do the medical and pharmaceutical research for them.This can lead to wrong being prescribed medicines and faulty Diagnostics.

What is hide doctors?

It is even more regrettable that hide in the middle of the ranks of honest medicine professionals, there are some doctors who do not want to help you obtain mejor.Los physicians make a lot of money out of patients becoming them again and again, and sometimes intentionally maintain information important to his patient, physician, or simply do not go to any length to find out what is really sick people.

Making your own medical and pharmaceutical research, it can put an end to best esto.La people informed of how their own bodies and if they are having good information, doctors more honest are forced to be.

You benefit from competition

The chances are good that the doctor is honest and just want ayudarle.Pero if you are doing research at home while the doctor is trying to help you in your Office, you can combine their easy conclusiones.Es find a multitude of stories about someone doing their own research and take a bit of information to your doctor which led to a test different, which led to a new procedure, which led to the patient is healed.

Never think that because it is not a medical professional can do medical research and farmaceutica.Se can make a world of good for you or loved ones to obtain information from reliable sources and bring to the attention of your doctor when algo.Incluso can open new doors and ideas, leading to a cure.

Mary Greene has written more than five years on a wide range of health issues and fitness.Ella has a background that includes such diverse areas as diabetes, asthma, yoga and mas.Si you want more information on medical research, please visit clinical research.

Article source: http://EzineArticles.com/?expert=Mary_Greene

Monday, November 22, 2010

The medical explanation about epilepsy

Epilepsy is functionally characterised by electrical discharge excessive recurring abnormal cerebral origin and clinically characterized by loss of excess of motor, sensory and Autonomic functions with or without alteration in consciousness. Epilepsy can be primary where there is no anatomically demonstrable abnormality of secondary when a local or diffuse injury is present.

Classification of epilepsy: Epilepsy has been classified in several ways.

I primary generalized Epilepsy: tonic clonic (grand mal) seizures of absence seizures (Petit mal), epilepsy, child spasms, Atonic seizures.

II seizures.partial: single - motor, sensory (somatic, Visual, auditory, olfactory), afectivo.Complejo - temporal lobe or psychomotor seizure.

Seizure III. partial secondary generalization.

Pathogenesis

The cortical neuron is abnormally excitable due to differentiation.The cell cells cytoplasmic membrane has increased permeability susceptible processing to activation by hyperthermia, hypoxia, hypoglycemia and hiponatremia.Deficiencia the inhibitory neurotransmitter benzioc gamma amino acid (GABA) and local regulation of extracellular potassium ions, ions of sodium, calcium ions alteration or magnesium ions are probably responsible for the instability of the membrane. This abnormal electrical discharge, if unchecked, extends the contralateral hemisphere of interhemispheric tracks and also the subcortical reticular brainstem nuclei, from where it feeds excitatory activity towards the rest of the cortex and basal ganglia structures. Most shapes called idiopathic epilepsy do not have any demonstrable injury in the brain. However, secondary types of epilepsy can have definable morbidas injuries. These include areas of neuronal loss and gliosis (scars), hamatomas, tumors and vascular malformations. One of the main clinical features is grand mal epilepsy.

Grand mal epilepsy: the paroxysm occurs at different stages sequentially. Stages can be subdivided into the prodromal phase, aura, tonic, clonic phase and the phase of postictal phase. Several hours before the prodromal stage start ictus (adjustment). Consists of several subjective phenomena as apathetic, or depressed mood irritability, cramping abdominal vague or other sensations intertitles, which are easily recognized by the patient often produces movements stereotyped as the rotation of the head or eye movement, grab the feeling in the epigastriun or a feeling unnatural body just before it is lost somewhere in the consciousness. This is called just before he loses consciousness. This is called the "aura" and often indicates activation of epileptic focus in the brain. In many cases, there is no any aura and the patient gets the attack without any warning.

Tonic phase consists of opening of the mouth and eyes associated with the kidnapping of arms, followed by adjustment of closure of the jaws, often resulting in injuries to the language and a cry as the entire musculature enters spasm forcing air from the closed vocal cords.The patient becomes cyanosed and can be the cancellation of the tough stage orina.Esta 10–15 segundos.La tonic phase is followed by the clonic phase characterised by substitute to and fro movement of all four limbs, sweating, produces foam of the mouth and the excessive salivation.The urine and feces can override.Clonic phase lasts 1-2 minutes.This is followed by a deep comatose States which takes about 5 minutes.Students are slowly beginning to react and the patient then resumes the intervention, but remains unclear.If left undisturbed, he enters sleep for several hours and often wakes up with headache severo.Se trafficking postictal phase and the patient cannot remember everything that has happened except the aura.

Electroencephalogram (EEG) taken during attacks, or sometimes even sample intervals abnormal electrical activity.

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Article source: http://EzineArticles.com/?expert=Funom_Makama

Funom Makama - EzineArticles Expert Author