Congenital neurosyphilis, Gunma slow virus infections of central nervous system

Stigma of occurring at birth include hydrocephalus, mental retardation, seizures, Chorioretinitis, atrophy optics and nerve deafness. These can be associated with other congenital syphilis evidence. Participation neurological develop later in congenital syphilis may take the form of injuries meningovascular, optic atrophy, tabes or GPI. The parenchymal lesions occur late at a much younger age (minor, GPI juvenile tabes).

Diagnosis: Neurosyphilis should be considered in the differential diagnosis of neurological disorders. GPI must differentiate disorders strokes, main dementias, space intra-beats injury and progressive degenerative lesions of occupation.Tabes should be considered in the differential diagnosis of lesions such as diabetic, toxic and nutritional neuropatheis heredofamilial, ataxia and siringomielia.Presencia Argyll Robertson pupil is a strength to support the diagnosis of neurosyphilis.

Diagnostic laboratory; Serology blood is positive in 60-70% of cases. Changes in the CSF are present in many.These include, Lymphocytic pleocytosis rises in proteins and curve colloidal gold one positive her (which can be tabetic or paretic) .the CSF changes depend on the disease activity. Pre-treatment tends to minimize disruptions.

Prognosis: Treatment can clarify meningovascular injury completely. The results are poor in cases established atrophy tabes and optc. GPI may occur a considerable improvement.

Treatment: It manages a penicilina.Cursos repeated may be required and this has to be decided depending on blood and CSF serology repeated at 6 and 12 months after the initial treatment. Dolores tabetic may respond to analgesics and carbamazepine in a dose of 100 mg three times daily. Visceral crisis discusses sedation and support measures.

Gumma central nervous system

Gumma occurs in the third stage of syphilis. pathologically, the Gumma consist of deposition of collagen, forming an amorphouse matric lymphocytes and multinucleated giant cells in the Center and edge plasma cells. T.pallidum is not provable in these lesiones.Marcelaa can be seen in various situations Cranial Dural, leptomeningeal, cerebral and spinal vertebral.estas behave like space-occupying lesions. antisyphilitic treatment response is poor.Line of treatment is excise duty injuries and give antisyphilitic therapy.

Syphilitic deafness: deafness may derive several reasons at different stages of the sifilis.puede result of affection of the cochlea, acoustic nerve, basal meninges or damage in ear half.

Slow virus infections

Some viruses are able to stay inactive in nervous tissue for long periods and produce damage during several years.These are characterized by long period of incubation, slow course progressive and in many cases a fetal termination.The following two groups are distinguished:

1. In the first group, viral agents are identifiable as Subacute Sclerosing Panencephalitis and progressive, multifocal leuconencephalopathy
2. In the second group, viruses have not been clearly identified, are resistant to antiviral medications, and them not evoke marked antibody response e.g., Kuru and Jakob-Crutzfeldt diseases.

Subacute Sclerosing Panencephalitis (SSPE) is caused by the measles virus.Occurs in children. cause serious anomalies intellectual functions and other motor disturbances and sensoriales.La disease follows a course of 3.9 months end fatalmente.En Kuru and Creutzfeldt Jakob - disease, there is strong evidence of a viral etiology, however, the real viruses have not been progressive multifocal identificados.Leucoencefalopatia (PML) is caused by a virus (SV 40 Jc Virus) Papoa .conduce to progressive demyelination occurring multifocally.PML is seen in partnership with the States of immunocompromised and lymphomas.

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Nutritional disorders of the nervous system

The central and peripheral nervous system may suffer deprivation of various nutrients. Pyridoxine (vitamin B6), thiamine (vitamin B1), cyanocobalamin (vitamin B12), Nicotinic Acid (vitamin B3), Pantothenic acid deficiencies are important among them.

Nutritional polyneuropathy: this may be the shortcomings of thiamine pyridoxine, cyanocobalamin, niacin, Pantothenic acid, alone or in combination.

Thiamin deficiency: this leads to neurological, cardiac or mal-efectos, is known as dry beriberi. Although originally described among people who subsist on rice polished as the main energy intake, the present beriberi is seen more among alcoholics. Neurologic injury takes the form of polyneuropathy symmetrical sensorimotor, characterized clinically by tingling, numbness and distal parts of the extremities.Motor phenomena are lower motor neuron bilateral lesions characterized by loss of two times ankle, gout and the fall of the wrist. There are deep, giving rise to the sensitivity of the calf hyperaesthesia. Some cases can develop Wernicke's encephalopathy.

Vitamin B12 deficiency resulting neuropathy can coexist with myelopathy in many cases.Neuropathy can be provable in 50-60% of subjects suffering from pellagra and subclinical deficiency of vitamin B6 deficiency niacina.La form produces polyneuropathy.More floridly is considered as a complication of isonicotinic acid (INH) hydrazide therapy.6 Mg of vitamin B6 administration prevents the development of this type of neuropathy.

Burning feet syndrome (also known as a condition in which the subject experience burning pain in the feet, especially Gopalan serious during the night, in order to interrupt the dream. examination may reveal cyanosis, excessive sweating, pallor, capillary dilation on both third pies.Una areas of these patients may show the sensibilidad.Mas loss often have may be presente.Muchos patients respond dramatically to injections of Pantothenic acid, suggesting that this vitamin deficiency can play an important role in the pathogenesis of the syndrome.)

Infections of central nervous system (neurosyphilis)

Infections usually involve the invasion of pathogenic microbes in systems of the body or bodies, causing damage or alteration of the organ or system functions. The type system is no exception and one invasive disorders is syphilitic lesions causing neurosyphilis and many infections that occur due to this, is the Meningovascular syphilis (tertiary neurosyphilis early).

Neurosyphilis

Involvement of the nervous system in syphilis used to be common before of the 1950s, but is now clearly rare to see new cases.Neurological injuries are caused by the invasion of the tissues by T.pallidum.Neurological involvement occurs in 4% of cases of syphilis without tratamiento.Hombres are affected 4-5 times more than the females. meningovascular participation is more common in the India, comprising 60-70% of the total.

Syphilitic injuries

1. Secondary meningitis stage
2 Stage tertiary
I Meningovascular syphilis: meningitis forms Basal Cerebral, pachymeningitis, vascular Thrombosis due to endarteritis, optic atrophy and Gumma. The backbone of forms-Meningomyelitis of Erb paraplegia cervical pachymeningitis, syphilitic amyotrophy, radiculitis, Gumma.
II. parenchymal participation: cerebral palsy generally Loco (IPG). Form of spinal vertebral Tabes dorsalis, optic atrophy.
3. Participation of congenital syphilis-Meningovascular atrophy optic, deafness, general paresis of the mentally ill and tabes.

Meningovascular syphilis (tertiary neurosyphilis early)

In this way, the most common injury is leptomeningitis. The lesions occur on the basis of the brain and hemispheres. Basal meningitis may involve cranisl cranial nerve palsies and occlusion of the hole towards the internal Hydrocephalus nerves. Main injury is endarteritis obliterans. The intimate is supplied, the vessel wall displays infiltration by plasma cells and lymphocytes. Supervenes in thrombosis and this obstructs the lumen.Granulomatous changes are also observed. Less often, duramater on cerebral hemispheres can participate in the process granulomatous thickening (cerebral pachymeningitis).

Clinical features

Brain forms: syphilitic meningitis sees in the 18-40 years age group.Basal syphilitic meningitis leads to a subacute or chronic meningitis which is characterized by headache, cranial nerve palsies, raised tension intra-beats and signs of meningeal irritation.CSF shows high protein and pleocytosis linfocitica.El sugar and chloride are normal.Cranial Pachymeningitis causes headaches, seizures and neurological deficit focus such as aphasia or hemiparesis.Syphilitic Endarteritis is one of the causes of Occlusive cerebrovascular youth injury.These cases present features of cerebral thrombosis.Facial paralysis of lower motor neuron can occur and the prognosis for recovery trigemino.El neuralgia is good if the condition is diagnosed early and treated.

The backbone of forms: This gives rise to the image of acute transverse myelitis or varying degrees of pain root cord compression.In some, develops spastic paraplegia.In this form (of Erb syphilic paraplegia) bladder dysfunction is common, but sensory symptoms are rare.

Hypertrophic cervical Pachymeningitis: cervical cord compression leads to pain root, weakness and wear of the upper limbs and erect and paraparesia.Tal image is also known as amyotrophy sifilitica.La cauda equina can be involved causing pain of root, areflexia, weakness and wear that affect the thighs and legs.

Optic atrophy: this may be meningo-vascular involvement or parenquimatosa.El first leads to arachnoiditis, optic neuritis or neuritis retrobulbares.estos changes occur during the tertiary phase sifilis.En this stage, no specific treatment can help reverse the condition. optic atrophy occurs as part of parenchymal participation during the final stages.

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Nutritional disorders of the nervous system and its manifestations

Some food nutrient deficiency can cause disorders of the body systems. The type system is no exception and disorders such as myelopathy, encephalopathy, visual disorders, malnutrition and slow development of the brain are all nutritional disorders of the nervous system.

Myelopathy

Demyelination can occur in lateral and subsequent columns of the spinal cord as a result of the deficiency of vitamin B12. Although it is mostly seen as a complication of pernicious anemia, can develop in resulting from causes of vitamin B12 deficiency.Myelopathy manifests as subacute combined degeneration, i.e. dysfunction pyramidal extensions and the subsequent columns.The other parts of the nervous system affected include peripheral nerves and optic nerves. the Neurologic injury and Hematological abnormalities (macrocytic anemia) coexist in many cases, but in some, neurologic injury may precede the anemia.Tratamiento with vitamin B12 always corrects anaemia, but if the condition is advanced neuropathy is irreversible.

Encephalopathy

Thiamin deficiency causes the classic example of nutritional encephalopathy, Wernicke's encephalopathy.The pathological changes include demyelination and Petechial haemorrhages in and around mammilary bodies and the third ventricle and aqueduct.Wernicke's encephalopathy can manifest modified palsies consciousness, ataxia, nystagmus and ocular.Una acute encephalopathy may develop in alcoholics and undernourished people who receive large doses of carbohydrates (especially glucose parenteral therapy) without concurrent tiamina.La management response to the parenteral administration of thiamine 100 mg is dramatic in such cases. Encephalopathy is a feature of Pellagra (niacin deficiency). East manifest as dementia, limbs, spasticity ataxia extrapyramindal riots.

Visual disturbances

Nutritional amblyopia can develop multiple nutrients including vitamin B12 deficiency. This value defines in insidiously with or vision, photophobia and discomfort of retrobulbar on how to move the eyes. Reduced visual acuity.Develop central or parenteral scotomas but peripheral vision fields can remain intact.Stracham syndrome is a combination of visual disturbances, ataxia, deafness and Mucocutaneous lesions.

Malnutrition and brain development

The human brain shows jets development between 15 to 20 weeks of gestation and growth continues for about two years after birth.The most important events are the proliferation of neurons and glial cells tracts myelination.Severe malnutrition (protein and energy) that occur during fetal life and in the early parts of children can leave behind the damage that not correctable by therapy posterior.Esta condition is quite common in desarrollo.A countries regret that the problem of child malnutrition is closely linked with the socio-economic and geographic factors is maximum public health importance to ensure adequate nutrition during pregnancy and lactation.

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